Nimesulide (N-4’-nitro-2’-phenoxyphenyl methane sulfonamide) is weakly acidic nonsteroidal anti-inflammatory drug (NSAID). Like many other NSAIDs, nimesulide is also very sparingly soluble in water. The very poor aqueous solubility and wettability of these drugs gives rise to difficulties in pharmaceutical formulations for oral or parenteral delivery, which may lead to variable bioavailability. The most important work on these drawbacks by increasing aqueous solubility of these drugs. The present work therefore aims to formulate Nimesulide immediate release tablets, by incorporation of super disintegrants in the formulation and evaluate overall efficiency of them. The tablets were prepared by direct compression method. The nimesulide-β-cyclodexrtin 1:2 M complex was prepared by Kneaded system and compressed on a Rinek single stroke punch machine. Hardness, friability, weight variation were within limits. Disintegration time of all formulations was within 15 min and dissolution profile of different formulations showed release complies with BP specifications.
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